Results

Publications

2022

  • Sonia Vela, Zulay D. Pardo Botero, Cristian Moya, Andres De la Escosura. Collective Adaptability in a Replication Network of Minimal Nucleobase Sequences. Chem. Sci., 2022, Accepted Manuscript, DOI: https://doi.org/10.1039/D2SC02419E
  • Jasper S. Möhler, Lena K. Beiersdörfer, Brenno Masina, Philipp Wechsler, Helma Wennemers. Tripeptide Organocatalysts for Stereoselective Conjugate Addition Reactions with N-Heterocyclic Substituents. Adv. Synth.Catal. 2022, 364, DOI: https://doi.org/10.1002/adsc.202200576 
  • Tobias Schnitzer, Jonas W. Rackl, Helma Wennemers. Stereoselective peptide catalysis in complex environments – from river water to cell lysates. Chemical Science 2022, 13, 31, 8963–8967; DOI:  https://doi.org/10.1039/d2sc02044k
  • Mathieu G. Baltussen, Jeroen van de Wiel, Cristina Lía Fernández Regueiro, Miglė Jakštaitė , and Wilhelm T. S. Huck. A Bayesian Approach to Extracting Kinetic Information from Artificial Enzymatic Networks. Anal. Chem. 2022, 94, 20, 7311–7318; DOI: https://doi.org/10.1021/acs.analchem.2c00659
  • Stefan Simić, Erna Zukić, Luca Schmermund, Kurt Faber, Christoph K. Winkler, and Wolfgang Kroutil. Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods. Chem. Rev. 2022, 122, 1, 1052-1126; DOI: 10.1021/acs.chemrev.1c00574

2021

  • Anil Kumar Bandela, Nathaniel Wagner, Hava Sadihov, Sara Morales-Reina, Agata Chotera-Ouda, Kingshuk Basu, Rivka Cohen-Luria, Andrés de la Escosura, Gonen Ashkenasy. Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks. PNAS. 2021, 118 (9) e2015285118; DOI: 10.1073/pnas.2015285118
  • Michael Teders, Aleksandr A. Pogodaev, Glenn Bojanov, Wilhelm T. S. Huck. Reversible Photoswitchable Inhibitors Generate Ultrasensitivity in Out-Of-Equilibrium Enzymatic Reactions. JACS. 2021, 143 (15), 5709–5716; DOI: 10.1021/jacs.0c12956
  • Michael Teders, Nicholas M. Murray, Wilhelm T. S. Huck. Reversible Photoswitchable Inhibitors Enable Wavelength-Selective Regulation of Out-of-Equilibrium Bi-Enzymatic Systems. ChemSystemsChem. 2021; DOI: 10.1002/syst.202100020
  • Christoph Winkler, Stefan Simić, Valentina Jurkaš, Sarah Bierbaumer, Luca Schmermund, Silvan Poschenrieder, Sarah A. Berger, Elisa Kulterer, Robert Kourist, and Wolfgang Kroutil. Accelerated Reaction Engineering of Photo(bio)catalytic Reactions through Parallelization with an Open-Source Photoreactor. ChemPhotoChem. 2021, 05; DOI: 10.1002/cptc.202100109
  • Helma Wennemers, Leo D. M. Nicholls. Synergistic Peptide and Gold Catalysis: Enantioselective Addition of Branched Aldehydes to Allenamides. Chem. Eur. J. 2021, 03; DOI: 10.1002/chem.202103197

2020

  • Jasper S. Möhler, Tobias Schnitzer, Helma Wennemers, Amine Catalysis with Substrates Bearing N-Heterocyclic Moieties Enabled by Control over the Enamine Pyramidalization Direction. Chem. Eur. J. 2020, 26, 15623 –15628; DOI: 10.1002/chem.202002966Adv. Synth.Catal.2022,364,

Conference contributions

2022

  • Stefan Simić, Christoph Winkler, Wolfgang Kroutil. Decarboxylation of palmitic acid catalyzed by Chlorella variabilis fatty-acid photodecarboxylase (CvFAP) in continuous flow, poster at the Biocatalysis Gordon Research Conference, 10-15 July 2022
  • Matthias Pickl, Jasper Möhler, Stefan Simic, Helma Wennemers, Wolfgang Kroutil. A single enzyme catalyzing two reactions – a biocatalytic oxidation Michale addition cascade, poster at the Biocatalysis Gordon Research Conference, 10-15 July 2022
  • Christoph Winkler, Stefan Simić, and Wolfgang Kroutil. Decarboxylation of palmitic acid catalyzed by Chlorella variabilis fatty-acid photodecarboxylase (CvFAP) in continuous flow, poster at the Biocatalysis Gordon Research Seminar, 9-10 July 2022
  • Andrés de la Escosura, Noemí Nogal, Santiago Guisán, Gonen Ashkenasy, Sonia Vela. Programming self-assembly and replication networks with minimal nucleobase sequences, poster at the Gordon Research Conference on Systems Chemistry, 26 June – 1 July 2022
  • Anil Kumar Bandela, Hava Sadihov, Andres de la Escosura, and Gonen Ashkenasy. Prebiotic Nucleopeptides as Non-enzymatic Replicators, poster at the Gordon Research Conference on Systems Chemistry, 26 June – 1 July 2022
  • Andrés de la Escosura. Programming Self- Assembly and Replication Networks with Minimal Nucleobase Sequences, lecture at the Gordon Research Conference on Systems Chemistry, 26 June – 1 July 2022
  • Gonen Ashkenasy. Signaling Motifs in Synthetic Systems: Data Analysis of Replication Networks Out-of-Equilibrium, oral presentation at the Gordon Research Conference on Systems Chemistry, 26 June – 1 July 2022

2021

  • Jasper S. Möhler, Helma Wennemers. N-heterocyclic substituted aldehydes in organocatalyzed conjugate addition reactions, poster at SCS Virtual Fall Meeting 2021, 10 September 2021
  • Stefan Simić, Christoph K. Winkler, Wolfgang Kroutil. Decarboxylation of palmitic acid catalyzed by Chlorella variabilis fatty-acid photodecarboxylase (CvFAP) – screening of reaction conditions in a custom-built photoreactor, poster at Flavins2021 – 20th international symposium on flavins and flavoproteins, 5 – 9 September 2021
  • Stefan Simić, Christoph K. Winkler, Wolfgang Kroutil. Screening of reaction conditions in the photobiocatalytic, poster at Biotrans 2021, 19 – 20 July 2021
  • Gonen Ashkenasy. The Systems Chemistry of Peptide Networks, oral presentation at 2021 Rutgers-NASA Enigma Astrobiology symposium, 8 June 2021
  • Andrés de la Escosura, Noemí Nogal, Marcos Sanz, Alonso Puente, Martin Aleksiev, Santiago Guisán, Sonia Vela. Biohybrid Materials in the Context of Systems Chemistry, oral presentation at Symposium on Biohybrid Nanomaterials of the E-MRS, Spring Meeting, 2 – 3 June 2021
  • Gonen Ashkenasy. Emergence of Function in Nucleopeptide networks Out of Equilibrium, oral presentation at 2021 Spring Meeting eMRS (virtual),  31 May 2021
  • Andrés de la Escosura, Noemí Nogal, Marcos Sanz, Alonso Puente, Martin Aleksiev, Santiago Guisán, Sonia Vela. Biohybrid Materials in the Context of Systems Chemistry, oral presentation at SupraBio2021, 10 – 12 May 2021
  • Andrés de la Escosura. Programming of self-assembly and replication networks with minimal nucleobase sequences, keynote lecture at 34th annual ILASOL meeting, 20 April 2021

2020

  • Alena Budinska, Tobias Schnitzer, Helma Wennemers. Organocatalyzed Conjugate Addition Reactions of Aldehydes to Nitroolefins with Anti-Selectivity, poster at Swiss Industrial Chemistry Symposium 2020, 30 October 2020
  • Christoph K. Winkler, Valentina Jurkaš, Luca Schmermund, Stefan Simic, Wolfgang Kroutil. Fast Reaction Engineering of Photobiocatalytic Reactions through Parallelization, poster at Young Chemists Summit, 21 – 23 September 2020
  • Stefan Simić, Christoph K. Winkler, Wolfgang Kroutil. Decarboxylation of palmitic acid catalyzed by Chlorella variabilis fatty-acid photodecarboxylase (CvFAP) in a custom-built photoreactor, poster at Young Chemists Summit, 21 – 23 September 2020
  • Christoph K. Winkler, Valentina Jurkaš, Luca Schmermund, Stefan Simic, Wolfgang Kroutil. Fast Reaction Engineering of Photobiocatalytic Reactions through Parallelization, poster at  27. Lecture Conference on Photochemistry, 14 – 15 September 2020
  • Stefan Simić, Christoph K. Winkler, Valentina Jurkaš, Wolfgang Kroutil. Light-dependent enzymatic decarboxylation of fatty carboxylic acids, poster at 27. Lecture Conference on Photochemistry, 14 – 15 September 2020
  • Christoph K. Winkler, Valentina Jurkaš, Luca Schmermund, Stefan Simic, Wolfgang Kroutil. Fast Reaction Engineering of Photobiocatalytic Reactions through Parallelization, poster at LatinXChem, 7 September 2020
  • Jasper S. Möhler, Tobias Schitzer, Helma Wennemers. Conformationally tailored peptides allow for amine catalysis with N-heterocyclic moieties, poster at SCS Fall Meeting 2020, 25 August 2020
  • Alena Budinska, Tobias Schnitzer, Helma Wennemers. Organocatalyzed Conjugate Addition Reactions of Aldehydes to Nitroolefins with Anti-Selectivity, poster at SCS Fall Meeting 2020, 25 August 2020
  • Sonia Vela, Noemí Nogal Rodríguez, Santiago Guisán, Chandan Giri, Andrés de la Escosura. The Informational Substrate of Chemical Evolution: Implications for Abiogenesis, poster at Molecular Origins of Life, Munich (held virtually), 8 – 10 July 2020
  • Sonia Vela, Noemí Nogal, Santiago Guisán, Chandan Giri, Andrés de la Escosura. Biohybrid Materials and Systems Chemistry, poster at Virtual Symposium on Systems Chemistry, 18 – 20 May 2020
  • Anil Kumar Bandela and Gonen Ashkenasy. Nucleopetides in prebiotic replication networks: A study demonstrating predominance in self-replicating nucleopeptides, oral presentation at 33rd annual ILASOL meeting, 3 March 2020

Event contributions

2022

  • Stefan Simić. Wer sind die Chemiker:innen der Natur? (Who are the chemists of nature?) Live demonstration at Lange Nacht der Forschung 2022, 20 May 2022
  • Miglė Jakštaitė. Cell-free biosynthesis of immobilised enzymes, oral presentation at PPIMM PhD Day, 17 May 2022

2020

  • Andrés de la Escosura. Emergence of Cell-Like Behaviour from Constitutional Dynamic Chemistry: Toward Biologically Inspired Autonomous Functional Systems, oral presentation at Virtual monitoring day 2020 of projects of the chemical sciences and technologies program, basic chemistry subprogram, 16 October 2020